effects of resveratrol on crosstalk between canonical β-catenin/wnt and foxo pathways in coronary artery disease patients with metabolic syndrome: a case control study

نویسندگان

mehrnoosh shanaki bavarsad department of biochemistry, school of medicine, tehran university of medical sciences, tehran, iran

taghi golmohammadi department of biochemistry, school of medicine, tehran university of medical sciences, tehran, iran

arash hossein-nezhad department of medicine, section of endocrinology, nutrition, and diabetes, vitamin d, skin and bone research laboratory, boston university medical center, boston, massachusetts, united states of america

reza meshkani department of biochemistry, school of medicine, tehran university of medical sciences, tehran, iran

چکیده

background: coronary artery disease (cad) is the major cause of mortality and morbidity worldwide. the aim of this study was to explore the effect of resveratrol (res) on canonical β-catenin/wnt and forkhead box o (foxo) pathways in cad patients.method: we performed this study on 10 metabolic syndrome patients with three-vessel cad and 10 sex-aged matched healthy subjects. the effects of res on β-catenin, manganese superoxide dismutase (mnsod), and peroxisome proliferator-activated receptor delta (ppar-δ) expression were evaluated in peripheral blood mononuclear cells (pbmcs) of participants. results: res could increase the mnsod expression in cad patients (38%, p

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Effects of resveratrol on crosstalk between canonical β-catenin/Wnt and FOXO pathways in coronary artery disease patients with metabolic syndrome: a case control study

Background: Coronary artery disease (CAD) is the major cause of mortality and morbidity worldwide. The aim of this study was to explore the effect of resveratrol (RES) on Canonical β-catenin/Wnt and forkhead box O (FOXO) pathways in CAD patients.Method: We performed this study on 10 metabolic syndrome patients with three-vessel CAD and 10 sex-aged matched healthy subjects. The effects of RES on...

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Effects of resveratrol on crosstalk between canonical β-catenin/Wnt and FOXO pathways in coronary artery disease patients with metabolic syndrome: a case control study

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عنوان ژورنال:
iranian journal of pharmaceutical research

جلد ۱۵، شماره ۳، صفحات ۵۴۷-۵۵۹

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